CK5/6 and GATA3 Defined Phenotypes of Muscle-Invasive Bladder Cancer: Impact in Adjuvant Chemotherapy and Molecular Subtyping of Negative Cases

CK5/6 and GATA3 Defined Phenotypes of Muscle-Invasive Bladder Cancer: Impact in Adjuvant Chemotherapy and Molecular Subtyping of Negative Cases

Introduction and ObjectiveIdentifying patients that benefit from cisplatin-based adjuvant chemotherapy is a major issue in the management of muscle-invasive bladder cancer (MIBC). The purpose of this study is to correlate “luminal” and “basal” type protein expression with histological subtypes, to i...

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Bibliographic Details
Main Authors: Florestan J. Koll, Alina Schwarz, Jens Köllermann, Severine Banek, Luis Kluth, Clarissa Wittler, Katrin Bankov, Claudia Döring, Nina Becker, Felix K.H. Chun, Peter J. Wild, Henning Reis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Medicine
Subjects:
bladder cancer
molecular subtyping
immunohistochemistry
adjuvant chemotherapy
double negative
consensus classification
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.875142/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.875142/full

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