A Class I HDAC Inhibitor Rescues Synaptic Damage and Neuron Loss in APP-Transfected Cells and APP/PS1 Mice through the GRIP1/AMPA Pathway

A Class I HDAC Inhibitor Rescues Synaptic Damage and Neuron Loss in APP-Transfected Cells and APP/PS1 Mice through the GRIP1/AMPA Pathway

As a neurodegenerative disease, Alzheimer’s disease (AD) seriously affects the health of older people. Changes in synapses occur first over the course of the disease, perhaps even before the formation of Aβ plaques. Histone deacetylase (HDAC) mediates the damage of Aβ oligomers to dendritic spines....

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Bibliographic Details
Main Authors: Ying Han, Le Chen, Jingyun Liu, Jie Chen, Chunyang Wang, Yu Guo, Xuebin Yu, Chenghong Zhang, Haiying Chu, Haiying Ma
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
Alzheimer’s disease
HDAC inhibitor
β-amyloid
synapse
AMPA receptor
Online Access:https://www.mdpi.com/1420-3049/27/13/4160

Internet

https://www.mdpi.com/1420-3049/27/13/4160

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