High interleukin-6 levels induced by COVID-19 pneumonia correlate with increased circulating follicular helper T cell frequency and strong neutralization antibody response in the acute phase of Omicron breakthrough infection

High interleukin-6 levels induced by COVID-19 pneumonia correlate with increased circulating follicular helper T cell frequency and strong neutralization antibody response in the acute phase of Omicron breakthrough infection

BackgroundAcute immune responses to coronavirus disease 2019 (COVID-19) are influenced by variants, vaccination, and clinical severity. Thus, the outcome of these responses may differ between vaccinated and unvaccinated patients and those with and without COVID-19-related pneumonia. In this study, t...

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Bibliographic Details
Main Authors: Hitoshi Kawasuji, Yoshitomo Morinaga, Kentaro Nagaoka, Hideki Tani, Yoshihiro Yoshida, Hiroshi Yamada, Yusuke Takegoshi, Makito Kaneda, Yushi Murai, Kou Kimoto, Hideki Niimi, Yoshihiro Yamamoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
Omicron
pneumonia
neutralizing antibody
interleukin-6
circulating follicular helper T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1377014/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1377014/full

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