Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation

Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation

Abstract Stimulator of interferon gene (STING) is increasingly exploited for the potential in cancer immunotherapy, yet its mechanism of activation remains not fully understood. Herein, we designed a novel STING agonist, designated as HB3089 that exhibits robust and durable anti-tumor activity in tu...

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Bibliographic Details
Main Authors: Zuoquan Xie, Zhen Wang, Fengying Fan, Jinpei Zhou, Zhaoxue Hu, Qingxia Wang, Xiyuan Wang, Qingzhong Zeng, Yan Zhang, Jiaxuan Qiu, Xiaoqian Zhou, Hui Xu, Hudagula Bai, Zhengsheng Zhan, Jian Ding, Huibin Zhang, Wenhu Duan, Xuekui Yu, Meiyu Geng
Format: Article
Language:English
Published: Nature Publishing Group 2022-12-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-022-00481-4

Internet

https://doi.org/10.1038/s41421-022-00481-4

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