A Triple Combination of Targeting Ligands Increases the Penetration of Nanoparticles across a Blood-Brain Barrier Culture Model

A Triple Combination of Targeting Ligands Increases the Penetration of Nanoparticles across a Blood-Brain Barrier Culture Model

Nanosized drug delivery systems targeting transporters of the blood-brain barrier (BBB) are promising carriers to enhance the penetration of therapeutics into the brain. The expression of solute carriers (SLC) is high and shows a specific pattern at the BBB. Here we show that targeting ligands ascor...

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Bibliographic Details
Main Authors: Szilvia Veszelka, Mária Mészáros, Gergő Porkoláb, Anikó Szecskó, Nóra Kondor, Györgyi Ferenc, Tamás F. Polgár, Gábor Katona, Zoltán Kóta, Lóránd Kelemen, Tibor Páli, Judit P. Vigh, Fruzsina R. Walter, Silvia Bolognin, Jens C. Schwamborn, Jeng-Shiung Jan, Mária A. Deli
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
blood-brain barrier
brain endothelial cell
drug targeting
nanoparticle
triple targeting ligand
solute carrier
Online Access:https://www.mdpi.com/1999-4923/14/1/86

Internet

https://www.mdpi.com/1999-4923/14/1/86

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