LZK-dependent stimulation of astrocyte reactivity promotes corticospinal axon sprouting

LZK-dependent stimulation of astrocyte reactivity promotes corticospinal axon sprouting

Injury to the adult mammalian central nervous system induces compensatory plasticity of spared axons—referred to as collateral axon sprouting—that can facilitate neural recovery. The contribution of reactive astrocytes to axon sprouting remains elusive. Here, we sought to investigate the role of axo...

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Bibliographic Details
Main Authors: Meifan Chen, Laura Ingle, Erik J. Plautz, Xiangmei Kong, Rui Tang, Neil Ghosh, Megan K. Romprey, William K. Fenske, Mark P. Goldberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
CNS injury
stroke
astrogliosis
reactive astrocytes
LZK/MAP3K13
axon plasticity
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.969261/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.969261/full

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