HuNoV Non-Structural Protein P22 Induces Maturation of IL-1β and IL-18 and N-GSDMD-Dependent Pyroptosis through Activating NLRP3 Inflammasome

HuNoV Non-Structural Protein P22 Induces Maturation of IL-1β and IL-18 and N-GSDMD-Dependent Pyroptosis through Activating NLRP3 Inflammasome

Norovirus infection is the leading cause of foodborne gastroenteritis worldwide, causing more than 200,000 deaths each year. As a result of a lack of reproducible and robust in vitro culture systems and suitable animal models for human norovirus (HuNoV) infection, the pathogenesis of HuNoV is still...

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Bibliographic Details
Main Authors: Nini Chen, Peiyu Chen, Yanhe Zhou, Sidong Chen, Sitang Gong, Ming Fu, Lanlan Geng
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Vaccines
Subjects:
HuNoV
P22
NLRP3 inflammasome
IL18
IL-1β
pyroptosis
Online Access:https://www.mdpi.com/2076-393X/11/5/993

Internet

https://www.mdpi.com/2076-393X/11/5/993

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