Conformational state-dependent regulation of GABAA receptor diffusion and subsynaptic domains

Conformational state-dependent regulation of GABAA receptor diffusion and subsynaptic domains

Summary: The efficacy of GABAergic synapses relies on the number of postsynaptic GABAA receptors (GABAARs), which is regulated by a diffusion capture mechanism. Here, we report that the conformational state of GABAARs influences their membrane dynamics. Indeed, pharmacological and mutational manipul...

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Bibliographic Details
Main Authors: Zaha Merlaud, Xavier Marques, Marion Russeau, Ursula Saade, Maelys Tostain, Imane Moutkine, Marc Gielen, Pierre-Jean Corringer, Sabine Lévi
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:iScience
Subjects:
Molecular biology
Neuroscience
Cellular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222017394

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http://www.sciencedirect.com/science/article/pii/S2589004222017394

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