Escape from Cellular Senescence Is Associated with Chromosomal Instability in Oral Pre-Malignancy

An escape from cellular senescence through the development of unlimited growth potential is one of the hallmarks of cancer, which is thought to be an early event in carcinogenesis. In this review, we propose that the molecular effectors of senescence, particularly the inactivation of TP53 and CDKN2A...

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Bibliographic Details
Main Authors: Stephen S. Prime, Nicola Cirillo, E. Kenneth Parkinson
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Biology
Subjects:
Online Access:https://www.mdpi.com/2079-7737/12/1/103