Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis

Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis

Abstract Background Dysregulation of nucleocytoplasmic shuttling of histone deacetylase 4 (HDAC4) is associated with several neurodevelopmental and neurodegenerative disorders. Consequently, understanding the roles of nuclear and cytoplasmic HDAC4 along with the mechanisms that regulate nuclear entr...

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Bibliographic Details
Main Authors: Wei Jun Tan, Hannah R. Hawley, Sarah J. Wilson, Helen L. Fitzsimons
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Biology
Subjects:
Drosophila
HDAC4
Histone deacetylase
Brain
Neuron
Mushroom body
Online Access:https://doi.org/10.1186/s12915-023-01800-1

Internet

https://doi.org/10.1186/s12915-023-01800-1

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