Insulin B-chain hybrid peptides are agonists for T cells reactive to insulin B:9-23 in autoimmune diabetes

Insulin B-chain hybrid peptides are agonists for T cells reactive to insulin B:9-23 in autoimmune diabetes

Insulin is considered to be a key antigenic target of T cells in Type 1 Diabetes (T1D) and autoimmune diabetes in the NOD mouse with particular focus on the B-chain amino acid sequence B:9-23 as the primary epitope. Our lab previously discovered that hybrid insulin peptides (HIPs), comprised of insu...

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Bibliographic Details
Main Authors: Janet M. Wenzlau, James E. DiLisio, Gene Barbour, Mylinh Dang, Anita C. Hohenstein, Maki Nakayama, Thomas Delong, Rocky L. Baker, Kathryn Haskins
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
autoimmune diabetes
T cell
insulin
B:9-23
NOD mouse
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.926650/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.926650/full

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