Identification and investigation of depression-related molecular subtypes in inflammatory bowel disease and the anti-inflammatory mechanisms of paroxetine

Identification and investigation of depression-related molecular subtypes in inflammatory bowel disease and the anti-inflammatory mechanisms of paroxetine

BackgroundUp to 40 per cent of people with active inflammatory bowel disease (IBD) also suffer from mood disorders such as anxiety and depression. Notwithstanding, the fundamental biological pathways driving depression in IBD remain unknown.MethodsWe identified 33 core genes that drive depression in...

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Bibliographic Details
Main Authors: Lijun Ning, Xinyuan Wang, Baoqin Xuan, Yanru Ma, Yuqing Yan, Ziyun Gao, Tianying Tong, Zhe Cui, Haoyan Chen, Xiaobo Li, Jie Hong, Zhenhua Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
inflammatory bowel disease
depression
non-negative matrix factorization
antidepressants
paroxetine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145070/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145070/full

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