Specification of the patterning of a ductal tree during branching morphogenesis of the submandibular gland

Abstract The development of ductal structures during branching morphogenesis relies on signals that specify ductal progenitors to set up a pattern for the ductal network. Here, we identify cellular asymmetries defined by the F-actin cytoskeleton and the cell adhesion protein ZO-1 as the earliest det...

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Bibliographic Details
Main Authors: Janice L. Walker, Weihao Wang, Edith Lin, Alison Romisher, Meghan P. Bouchie, Brigid Bleaken, A. Sue Menko, Maria A. Kukuruzinska
Format: Article
Language:English
Published: Nature Portfolio 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79650-y