Doxorubicin-Loaded Polymeric Micelles Conjugated with CKR- and EVQ-FLT3 Peptides for Cytotoxicity in Leukemic Stem Cells

Doxorubicin-Loaded Polymeric Micelles Conjugated with CKR- and EVQ-FLT3 Peptides for Cytotoxicity in Leukemic Stem Cells

Doxorubicin (Dox) is the standard chemotherapeutic agent for acute myeloblastic leukemia (AML) treatment. However, 40% of Dox-treated AML cases relapsed due to the presence of leukemic stem cells (LSCs). Thus, poloxamer 407 and CKR- and EVQ-FLT3 peptides were used to formulate Dox-micelles (DMs) and...

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Bibliographic Details
Main Authors: Fah Chueahongthong, Singkome Tima, Sawitree Chiampanichayakul, Pornngarm Dejkriengkraikul, Siriporn Okonogi, Mathurada Sasarom, Soraya Rodwattanagul, Cory Berkland, Songyot Anuchapreeda
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceutics
Subjects:
doxorubicin
CKR
EVQ
polymeric micelle
leukemic stem cell
co-treatment
Online Access:https://www.mdpi.com/1999-4923/14/10/2115

Internet

https://www.mdpi.com/1999-4923/14/10/2115

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