Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis.

Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis.

Prostaglandin I(2) (PGI(2)), a lipid mediator currently used in treatment of human disease, is a critical regulator of adaptive immune responses. Although PGI(2) signaling suppressed Th1 and Th2 immune responses, the role of PGI(2) in Th17 differentiation is not known.In mouse CD4(+)CD62L(+) naïve T...

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Bibliographic Details
Main Authors: Weisong Zhou, Dustin R Dowell, Matthew M Huckabee, Dawn C Newcomb, Madison G Boswell, Kasia Goleniewska, Matthew T Lotz, Shinji Toki, Huiyong Yin, Songyi Yao, Chandramohan Natarajan, Pingsheng Wu, Subramaniam Sriram, Richard M Breyer, Garret A Fitzgerald, R Stokes Peebles
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3349674?pdf=render

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http://europepmc.org/articles/PMC3349674?pdf=render

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