S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice
S14G-humanin (HNG), an analog of the mitochondria-derived peptide humanin, has demonstrated protective effects against various cardiovascular diseases. However, the specific pharmacological effects of HNG in heart failure (HF) have not been previously reported. Therefore, in this study, we aimed to...
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Elsevier
2023-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023091004 |
| _version_ | 1827615898530217984 |
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| author | Qi Zhao Ming-Ming Cai Dan Li Bin-Yi Zhao Shuang-Shan Zhou Zhen-Ru Wu Yu-Jun Shi Li Su |
| author_facet | Qi Zhao Ming-Ming Cai Dan Li Bin-Yi Zhao Shuang-Shan Zhou Zhen-Ru Wu Yu-Jun Shi Li Su |
| author_sort | Qi Zhao |
| collection | DOAJ |
| description | S14G-humanin (HNG), an analog of the mitochondria-derived peptide humanin, has demonstrated protective effects against various cardiovascular diseases. However, the specific pharmacological effects of HNG in heart failure (HF) have not been previously reported. Therefore, in this study, we aimed to investigate the potential protective effect of HNG in HF using a mouse model. HF was induced in mice through intraperitoneal injection of isoproterenol or transverse aortic constriction, followed by separate administration of HNG to assess its therapeutic impact. Our results revealed that HNG treatment significantly delayed the onset of cardiac dysfunction and structural remodeling in the HF mouse model. Furthermore, HNG administration was associated with reduced infiltration of inflammatory cells, improved myocardial fibrosis, and attenuation of cardiomyocyte apoptosis in the treated cardiac tissues. Additionally, we identified the involvement of the transforming growth factor-beta signaling pathway in the beneficial effects of HNG in isoproterenol-induced HF mice. Collectively, these findings underscore the therapeutic potential of HNG in preventing the progression of HF, as demonstrated in two distinct HF mouse models. |
| first_indexed | 2024-03-09T09:18:13Z |
| format | Article |
| id | doaj.art-d7751c7546314afa95f2068e8b1c7b1b |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-09T09:18:13Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-d7751c7546314afa95f2068e8b1c7b1b2023-12-02T07:04:35ZengElsevierHeliyon2405-84402023-11-01911e21892S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in miceQi Zhao0Ming-Ming Cai1Dan Li2Bin-Yi Zhao3Shuang-Shan Zhou4Zhen-Ru Wu5Yu-Jun Shi6Li Su7Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, ChinaLaboratory of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, ChinaLaboratory of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China; Corresponding author. Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 288 Tianwen Avenue, Nan'an District, Chongqing, 401336, China.S14G-humanin (HNG), an analog of the mitochondria-derived peptide humanin, has demonstrated protective effects against various cardiovascular diseases. However, the specific pharmacological effects of HNG in heart failure (HF) have not been previously reported. Therefore, in this study, we aimed to investigate the potential protective effect of HNG in HF using a mouse model. HF was induced in mice through intraperitoneal injection of isoproterenol or transverse aortic constriction, followed by separate administration of HNG to assess its therapeutic impact. Our results revealed that HNG treatment significantly delayed the onset of cardiac dysfunction and structural remodeling in the HF mouse model. Furthermore, HNG administration was associated with reduced infiltration of inflammatory cells, improved myocardial fibrosis, and attenuation of cardiomyocyte apoptosis in the treated cardiac tissues. Additionally, we identified the involvement of the transforming growth factor-beta signaling pathway in the beneficial effects of HNG in isoproterenol-induced HF mice. Collectively, these findings underscore the therapeutic potential of HNG in preventing the progression of HF, as demonstrated in two distinct HF mouse models.http://www.sciencedirect.com/science/article/pii/S2405844023091004S14G-humaninHeart failureCardiac remodelingTGF-β |
| spellingShingle | Qi Zhao Ming-Ming Cai Dan Li Bin-Yi Zhao Shuang-Shan Zhou Zhen-Ru Wu Yu-Jun Shi Li Su S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice Heliyon S14G-humanin Heart failure Cardiac remodeling TGF-β |
| title | S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice |
| title_full | S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice |
| title_fullStr | S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice |
| title_full_unstemmed | S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice |
| title_short | S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice |
| title_sort | s14g humanin confers cardioprotective effects against chronic adrenergic and pressure overload induced heart failure in mice |
| topic | S14G-humanin Heart failure Cardiac remodeling TGF-β |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023091004 |
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