Cross-company evaluation of the human lymphocyte activation assay

Cross-company evaluation of the human lymphocyte activation assay

Nonclinical immunotoxicity evaluation is an important component of safety assessment for pharmaceuticals. One in vitro assay that can be applied in a weight of evidence assessment is the human lymphocyte activation (HuLA) assay, an antigen recall assay, similar in many respects to the in vivo T-cell...

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Bibliographic Details
Main Authors: Mark Collinge, Patricia Schneider, Dingzhou Li, Stanley Parish, Carolyne Dumont, Wendy Freebern, Joseph Ghanime, Fanny Guimont-Derochers, Anja Langenkamp, Jose Lebron, Nianyu Li, Celine Marban, Lisa Plitnick, Jennifer Wheeler
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Immunotoxicology
Subjects:
immune
in vitro assay
influenza
immunosuppression
pbmc
cyclosporine
mycophenolate
Online Access:http://dx.doi.org/10.1080/1547691X.2020.1725694

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http://dx.doi.org/10.1080/1547691X.2020.1725694

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