Current challenges and therapeutic advances of CAR-T cell therapy for solid tumors

Current challenges and therapeutic advances of CAR-T cell therapy for solid tumors

Abstract The application of chimeric antigen receptor (CAR) T cells in the management of hematological malignancies has emerged as a noteworthy therapeutic breakthrough. Nevertheless, the utilization and effectiveness of CAR-T cell therapy in solid tumors are still limited primarily because of the a...

Full description

Bibliographic Details
Main Authors: Tong Chen, Mingzhao Wang, Yanchao Chen, Yutao Liu
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cancer Cell International
Subjects:
CAR T cell therapy
Solid tumor
Tumor microenvironment
Antigen
Heterogeneity
T cell exhaustion
Online Access:https://doi.org/10.1186/s12935-024-03315-3

Internet

https://doi.org/10.1186/s12935-024-03315-3

Similar Items