Synthesis, Antimycobacterial Activity and In Vitro Cytotoxicity of 5-Chloro-N-phenylpyrazine-2-carboxamides

Synthesis, Antimycobacterial Activity and In Vitro Cytotoxicity of 5-Chloro-N-phenylpyrazine-2-carboxamides

5-Chloropyrazinamide (5-Cl-PZA) is an inhibitor of mycobacterial fatty acid synthase I with a broad spectrum of antimycobacterial activity in vitro. Some N-phenylpyrazine-2-carboxamides with different substituents on both the pyrazine and phenyl core possess significant in vitro activity against My...

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Bibliographic Details
Main Authors: Jan Zitko, Barbora Servusová, Pavla Paterová, Jana Mandíková, Vladimír Kubíček, Radim Kučera, Veronika Hrabcová, Jiří Kuneš, Ondřej Soukup, Martin Doležal
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Molecules
Subjects:
pyrazinamide
5-chloropyrazinamide
anilides
antimycobacterial activity
cytotoxicity
Online Access:http://www.mdpi.com/1420-3049/18/12/14807

Internet

http://www.mdpi.com/1420-3049/18/12/14807

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