Methylation of ESR1 promoter induced by SNAI2–DNMT3B complex promotes epithelial–mesenchymal transition and correlates with poor prognosis in ERα‐positive breast cancers

Methylation of ESR1 promoter induced by SNAI2–DNMT3B complex promotes epithelial–mesenchymal transition and correlates with poor prognosis in ERα‐positive breast cancers

Abstract Estrogen receptor α (ERα) serves as an essential therapeutic predictor for breast cancer (BC) patients and is regulated by epigenetic modification. Abnormal methylation of cytosine phosphoric acid guanine islands in the estrogen receptor 1 (ESR1) gene promoter could silence or decrease ERα...

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Bibliographic Details
Main Authors: Ji‐Wei Li, Qiu‐Min Deng, Jian‐Ling Zhu, Wei Min, Xiao‐Yi Hu, Hong‐ Yu Chen, Zhong Luo, Lin‐Ling Lin, Xiao‐Long Wei, Yong‐Qu Zhang, Kang‐Liang Lou, Yi‐Yang Gao, Guo‐Jun Zhang, Jing‐Wen Bai
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:MedComm
Subjects:
breast cancer
DNA methyltransferase 3 beta
epithelial–mesenchymal transition
ESR1 methylation
snail family transcriptional repressor 2
Online Access:https://doi.org/10.1002/mco2.403

Internet

https://doi.org/10.1002/mco2.403

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