Molecular evolution of HIV-1 integrase during the 20 years prior to the first approval of integrase inhibitors

Molecular evolution of HIV-1 integrase during the 20 years prior to the first approval of integrase inhibitors

Abstract Background Detailed knowledge of the evolutionary potential of polymorphic sites in a viral protein is important for understanding the development of drug resistance in the presence of an inhibitor. We therefore set out to analyse the molecular evolution of the HIV-1 subtype B integrase at...

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Bibliographic Details
Main Authors: Karolin Meixenberger, Kaveh Pouran Yousef, Maureen Rebecca Smith, Sybille Somogyi, Stefan Fiedler, Barbara Bartmeyer, Osamah Hamouda, Norbert Bannert, Max von Kleist, Claudia Kücherer
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Virology Journal
Subjects:
HIV
Integrase
Drug resistance
Polymorphisms
Time trend
Covariation
Online Access:http://link.springer.com/article/10.1186/s12985-017-0887-1

Internet

http://link.springer.com/article/10.1186/s12985-017-0887-1

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