Negative E-cadherin expression on bone marrow myeloma cell membranes is associated with extramedullary disease [version 2; peer review: 2 approved]

Background: The loss of E-cadherin expression and the induction of N-cadherin are known as hallmarks of the epithelial-to-mesenchymal transition, an essential initial step in the process of metastasis in solid tumors. Although several studies have reported expressions of these cadherins in patients...

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Main Authors: Yutaka Hattori, Shinichiro Okamoto, Ryunosuke Denda, Hisako Kunieda, Hiroki Sugimori, Takahide Kikuchi, Shigemichi Hirose, Kiyoshi Mukai, Yuiko Tsukada, Makoto Osada, Maki Hirao, Kentaro Watanabe, Kohei Yamazaki
Format: Article
Language:English
Published: F1000 Research Ltd 2022-11-01
Series:F1000Research
Subjects:
Online Access:https://f1000research.com/articles/11-245/v2