The Distinctive Activation of Toll-Like Receptor 4 in Human Samples with Sepsis

The Distinctive Activation of Toll-Like Receptor 4 in Human Samples with Sepsis

Clinical success of Toll-Like receptor-4 (TLR-4) antagonists in sepsis therapy has thus far been lacking. As inhibition of a receptor can only be useful if the receptor is active, stratification of patients with active TLR-4 would be desirable. Our aim was to establish an assay to quantify phosphory...

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Bibliographic Details
Main Authors: Patrick Thon, Katharina Rump, Annika Knorr, Birte Dyck, Dominik Ziehe, Matthias Unterberg, Hartmuth Nowak, Lars Bergmann, Alexander Wolf, Maha Bazzi, Jennifer Orlowski, Marcus Peters, Alexander Zarbock, Thorsten Brenner, Michael Adamzik, Tim Rahmel, Björn Koos
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
sepsis
Toll-Like Receptor 4
proximity ligation assay
Online Access:https://www.mdpi.com/2073-4409/11/19/3020

Internet

https://www.mdpi.com/2073-4409/11/19/3020

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