Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver diseaseResearch in context

Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver diseaseResearch in context

Summary: Background: Non-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed, epidemic. We hypothesise that obesity-related inflammation compromises adipose tissue functions, preventing efficient fat storage, and thus driving ectopic fat accumulation into the liver. Methods: To...

Full description

Bibliographic Details
Main Authors: Nicholas Darci-Maher, Marcus Alvarez, Uma Thanigai Arasu, Ilakya Selvarajan, Seung Hyuk T. Lee, David Z. Pan, Zong Miao, Sankha Subhra Das, Dorota Kaminska, Tiit Örd, Jihane N. Benhammou, Martin Wabitsch, Joseph R. Pisegna, Ville Männistö, Kirsi H. Pietiläinen, Markku Laakso, Janet S. Sinsheimer, Minna U. Kaikkonen, Jussi Pihlajamäki, Päivi Pajukanta
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:EBioMedicine
Subjects:
Serum biomarkers
Non-alcoholic fatty liver disease
Obesity
Dual-tissue transcriptomics screening
Liver histology
Adipogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423001858

Internet

http://www.sciencedirect.com/science/article/pii/S2352396423001858

Similar Items