The Safety and Efficacy of Combining Saxagliptin and Pioglitazone Therapy in Streptozocin-Induced Diabetic Rats

The Safety and Efficacy of Combining Saxagliptin and Pioglitazone Therapy in Streptozocin-Induced Diabetic Rats

Background: Type 2 diabetes mellitus (T2DM) is a chronic progressive disease due to insulin resistance. Oxidative stress complicates the etiology of T2DM. Saxagliptin is a selective dipeptidyl peptidase-4 (DPP-4) inhibitor, while Pioglitazone is a thiazolidinedione insulin sensitizer. This study aim...

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Bibliographic Details
Main Authors: Ahmed Mohamed Othman, Ibrahim Ashour Ibrahim, Samy M. Saleh, Dina M. Abo-Elmatty, Noha M. Mesbah, Asmaa R. Abdel-Hamed
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Biomedicines
Subjects:
diabetes mellitus
Saxagliptin
Pioglitazone
miRNA-29a
oxidative stress
Online Access:https://www.mdpi.com/2227-9059/11/12/3300

Internet

https://www.mdpi.com/2227-9059/11/12/3300

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