Neutral Effects of Combined Treatment With GLP-1R Agonist Exenatide and MR Antagonist Potassium Canrenoate on Cardiac Function in Porcine and Murine Chronic Heart Failure Models

Neutral Effects of Combined Treatment With GLP-1R Agonist Exenatide and MR Antagonist Potassium Canrenoate on Cardiac Function in Porcine and Murine Chronic Heart Failure Models

Background: Ischemia-reperfusion and cardiac remodeling is associated with cardiomyocyte death, excessive fibrosis formation, and functional decline, eventually resulting in heart failure (HF). Glucagon-like peptide (GLP)-1 agonists are reported to reduce apoptosis and myocardial infarct size after...

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Bibliographic Details
Main Authors: Evelyne J. Demkes, Steven Wenker, Max J. M. Silvis, Martijn M. J. van Nieuwburg, M. Joyce Visser, Marlijn S. Jansen, Maike A. D. Brans, Evelyn Velema, Joost P. G. Sluijter, Imo E. Hoefer, Dominique P. V. de Kleijn, Leo Timmers, Saskia C. A. de Jager
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
chronic heart failure
glucagon-like peptide-1 agonist
mineralocorticoid receptor antagonist
porcine
mouse
myocardial infarction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.702326/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.702326/full

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