Molecular and Pathological Analyses of IARS1-Deficient Mice: An IARS Disorder Model

Molecular and Pathological Analyses of IARS1-Deficient Mice: An IARS Disorder Model

Most mitochondrial diseases are hereditary and highly heterogeneous. Cattle born with the V79L mutation in the isoleucyl-tRNA synthetase 1 (IARS1) protein exhibit weak calf syndrome. Recent human genomic studies about pediatric mitochondrial diseases also identified mutations in the IARS1 gene. Alth...

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Bibliographic Details
Main Authors: Masaki Watanabe, Koya Shishido, Nao Kanehira, Koki Hiura, Kenta Nakano, Tadashi Okamura, Ryo Ando, Hayato Sasaki, Nobuya Sasaki
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondrial diseases
hepatic triglyceride
serum ornithine carbamoyltransferase
weak calf syndrome
Online Access:https://www.mdpi.com/1422-0067/24/8/6955

Internet

https://www.mdpi.com/1422-0067/24/8/6955

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