Mono-(2-ethylhexyl) Phthalate (MEHP)-Induced Telomere Structure and Function Disorder Mediates Cell Cycle Dysregulation and Apoptosis via c-Myc and Its Upstream Transcription Factors in a Mouse Spermatogonia-Derived (GC-1) Cell Line

Mono-(2-ethylhexyl) Phthalate (MEHP)-Induced Telomere Structure and Function Disorder Mediates Cell Cycle Dysregulation and Apoptosis via c-Myc and Its Upstream Transcription Factors in a Mouse Spermatogonia-Derived (GC-1) Cell Line

As a typical environmental endocrine disrupting chemical (EDC), di-(2-ethylhexyl) phthalate (DEHP) is thought to be related to reproductive disorders, especially in males. Growing evidence suggests that various EDCs may result in an impaired telomere structure and function, which is associated with...

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Bibliographic Details
Main Authors: Fangji Zhou, Chengwei Guo, Lingqiao Wang, Guowei Zhang, Jia Wang, Weiyan Chen, Ke Cui, Yao Tan, Ziyuan Zhou
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Toxics
Subjects:
mono-(2-ethylhexyl) phthalate
telomere dysfunction
G<sub>0</sub>/G<sub>1</sub> phase cell cycle arrest
apoptosis
TERT
c-Myc
Online Access:https://www.mdpi.com/2305-6304/11/5/448

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https://www.mdpi.com/2305-6304/11/5/448

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