Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors

Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors

Summary: Spatial relationships between Cav channels and release sensors at active zones (AZs) are a major determinant of synaptic fidelity. They are regulated developmentally, but the underlying molecular mechanisms are largely unclear. Here, we show that Munc13-3 regulates the density of Cav2.1 and...

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Bibliographic Details
Main Authors: Valentin Kusch, Grit Bornschein, Desiree Loreth, Julia Bank, Johannes Jordan, David Baur, Masahiko Watanabe, Akos Kulik, Manfred Heckmann, Jens Eilers, Hartmut Schmidt
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Subjects:
coupling
nanodomain
synapse
active zone
development
Ca2+ channels
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718301785

Internet

http://www.sciencedirect.com/science/article/pii/S2211124718301785

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