Lactate Attenuates Synaptic Transmission and Affects Brain Rhythms Featuring High Energy Expenditure

Summary: Lactate shuttled from blood, astrocytes, and/or oligodendrocytes may serve as the major glucose alternative in brain energy metabolism. However, its effectiveness in fueling neuronal information processing underlying complex cortex functions like perception and memory is unclear. We show th...

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Bibliographic Details
Main Authors: Jan-Oliver Hollnagel, Tiziana Cesetti, Justus Schneider, Alina Vazetdinova, Fliza Valiullina-Rakhmatullina, Andrea Lewen, Andrei Rozov, Oliver Kann
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220305034