Engineering Bafilomycin High-Producers by Manipulating Regulatory and Biosynthetic Genes in the Marine Bacterium <i>Streptomyces lohii</i>

Engineering Bafilomycin High-Producers by Manipulating Regulatory and Biosynthetic Genes in the Marine Bacterium <i>Streptomyces lohii</i>

Bafilomycin A<sub>1</sub> is the representative compound of the plecomacrolide natural product family. This 16-membered ring plecomacrolide has potent antifungal and vacuolar H<sup>+</sup>-ATPase inhibitory activities. In our previous work, we identified a bafilomycin biosynt...

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Bibliographic Details
Main Authors: Zhong Li, Shuai Li, Lei Du, Xingwang Zhang, Yuanyuan Jiang, Wenhua Liu, Wei Zhang, Shengying Li
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Marine Drugs
Subjects:
<i>Streptomyces</i>
bafilomycin
regulatory gene
biosynthesis
fermentation optimization
Online Access:https://www.mdpi.com/1660-3397/19/1/29

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https://www.mdpi.com/1660-3397/19/1/29

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