RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements

RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements

Receptor tyrosine kinases exhibit a variety of activation mechanisms despite highly homologous catalytic domains. Such diversity arises through coupling of extracellular ligand-binding portions with highly variable intracellular sequences flanking the tyrosine kinase domain and specific patterns of...

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Bibliographic Details
Main Authors: Iván Plaza-Menacho, Karin Barnouin, Rachael Barry, Annabel Borg, Mariam Orme, Rakhee Chauhan, Stephane Mouilleron, Rubén J. Martínez-Torres, Pascal Meier, Neil Q. McDonald
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Cell Reports
Subjects:
receptor tyrosine kinase
RTK
structure-function
phosphorylation
dual-specificity
signaling
oncogene
Drosophila
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716316345

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http://www.sciencedirect.com/science/article/pii/S2211124716316345

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