ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

Summary: Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS). ADAR1 converts adenosines into inosines within dsRNA. This process called A-to-I editing masks self-dsRNA from detection by th...

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Bibliographic Details
Main Authors: Richard de Reuver, Evelien Dierick, Bartosz Wiernicki, Katrien Staes, Leen Seys, Ellen De Meester, Tuur Muyldermans, Alexander Botzki, Bart N. Lambrecht, Filip Van Nieuwerburgh, Peter Vandenabeele, Jonathan Maelfait
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
A-to-I editing
Aicardi-Goutières syndrome
AGS
Z-DNA
IFIH1
MAVS
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721009281

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http://www.sciencedirect.com/science/article/pii/S2211124721009281

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