Rare coding variants in NOX4 link high ROS levels to psoriatic arthritis mutilans

Rare coding variants in NOX4 link high ROS levels to psoriatic arthritis mutilans

Abstract Psoriatic arthritis mutilans (PAM) is the rarest and most severe form of psoriatic arthritis, characterized by erosions of the small joints and osteolysis leading to joint disruption. Despite its severity, the underlying mechanisms are unknown, and no susceptibility genes have hitherto been...

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Bibliographic Details
Main Authors: Sailan Wang, Pernilla Nikamo, Leena Laasonen, Bjorn Gudbjornsson, Leif Ejstrup, Lars Iversen, Ulla Lindqvist, Jessica J Alm, Jesper Eisfeldt, Xiaowei Zheng, Sergiu-Bogdan Catrina, Fulya Taylan, Raquel Vaz, Mona Ståhle, Isabel Tapia-Paez
Format: Article
Language:English
Published: Springer Nature 2024-02-01
Series:EMBO Molecular Medicine
Subjects:
NADPH Oxidase 4 (NOX4)
Psoriatic Arthritis Mutilans
Reactive Oxygen Species (ROS)
Hydrogen Peroxide
Osteoclast Differentiation
Online Access:https://doi.org/10.1038/s44321-024-00035-z

Internet

https://doi.org/10.1038/s44321-024-00035-z

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