Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells

Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells

Summary: Differentiation of astrocytes from human pluripotent stem cells (hPSCs) is a tedious and variable process. This hampers the study of hPSC-generated astrocytes in disease processes and drug development. By using CRISPR/Cas9-mediated inducible expression of NFIA or NFIA plus SOX9 in hPSCs, we...

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Bibliographic Details
Main Authors: Xiang Li, Yezheng Tao, Robert Bradley, Zhongwei Du, Yunlong Tao, Linghai Kong, Yi Dong, Jeffrey Jones, Yuanwei Yan, Cole R.K. Harder, Lindsay Morgan Friedman, Magd Bilal, Brianna Hoffmann, Su-Chun Zhang
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671118303631

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http://www.sciencedirect.com/science/article/pii/S2213671118303631

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