Macrophage polarization in rheumatoid arthritis: signaling pathways, metabolic reprogramming, and crosstalk with synovial fibroblasts

Macrophage polarization in rheumatoid arthritis: signaling pathways, metabolic reprogramming, and crosstalk with synovial fibroblasts

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. Macrophages are key effector cells that play a central role in RA pathogenesis through their ability to polarize into distinct functional phenotypes. An imba...

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Bibliographic Details
Main Authors: Yixin Zheng, Kai Wei, Ping Jiang, Jianan Zhao, Yu Shan, Yiming Shi, Fuyu Zhao, Cen Chang, Yunshen Li, Mi Zhou, Xinliang Lv, Shicheng Guo, Dongyi He
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
inflammation
macrophages
macrophage polarization
fibroblasts
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1394108/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1394108/full

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