Unwinding the mechanism of macrophage repolarization potential of Oceanimonas sp. BPMS22-derived protein protease inhibitor through Toll-like receptor 4 against experimental visceral leishmaniasis

Unwinding the mechanism of macrophage repolarization potential of Oceanimonas sp. BPMS22-derived protein protease inhibitor through Toll-like receptor 4 against experimental visceral leishmaniasis

The Oceanimonas sp. BPMS22-derived protein protease inhibitor (PPI) has been proven to shift macrophages towards an inflammatory state and reduce Leishmania donovani infection in vitro and in vivo. The current study explored and validated the mechanistic aspects of the PPI and Toll-like receptor (TL...

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Bibliographic Details
Main Authors: Adithyan Jayaraman, Sujatha Srinivasan, Kiran Babu Uppuluri, Santanu Kar Mahapatra
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Oceanimonas sp. BPMS22
immunotherapy
innate immune response
visceral leishmaniasis
macrophage repolarization
Toll-like receptor 4
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1120888/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2023.1120888/full

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