Mast Cell-Derived Proteases Induce Endothelial Permeability and Vascular Damage in Severe Fever with Thrombocytopenia Syndrome

Mast Cell-Derived Proteases Induce Endothelial Permeability and Vascular Damage in Severe Fever with Thrombocytopenia Syndrome

ABSTRACT Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever acquired by tick bites. Whether mast cells (MCs), the body’s first line of defense against pathogens, might influence immunity or pathogenesis during SFTS virus (SFTSV) infection remained unknown. Here, we f...

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Bibliographic Details
Main Authors: Yu-Na Wang, Yun-Fa Zhang, Xue-Fang Peng, Hong-Han Ge, Gang Wang, Heng Ding, Yue Li, Shuang Li, Ling-Yu Zhang, Jing-Tao Zhang, Hao Li, Xiao-Ai Zhang, Wei Liu
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:Microbiology Spectrum
Subjects:
SFTSV
chymase
mast cell
tryptase
vascular damage
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01294-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.01294-22

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