Cationic Peptidomimetic Amphiphiles Having a <i>N</i>-Aryl- or <i>N</i>-Naphthyl-1,2,3-Triazole Core Structure Targeting <i>Clostridioides</i> (<i>Clostridium</i>) <i>difficile</i>: Synthesis, Antibacterial Evaluation, and an In Vivo <i>C. difficile</i> Infection Model

Cationic Peptidomimetic Amphiphiles Having a <i>N</i>-Aryl- or <i>N</i>-Naphthyl-1,2,3-Triazole Core Structure Targeting <i>Clostridioides</i> (<i>Clostridium</i>) <i>difficile</i>: Synthesis, Antibacterial Evaluation, and an In Vivo <i>C. difficile</i> Infection Model

<i>Clostridioides</i> (also known as <i>Clostridium</i>) <i>difficile</i> is a Gram-positive anaerobic, spore producing bacterial pathogen that causes severe gastrointestinal infection in humans. The current chemotherapeutic options are inadequate, expensive, and...

Full description

Bibliographic Details
Main Authors: Muni Kumar Mahadari, Sreenu Jennepalli, Andrew J. Tague, Papanin Putsathit, Melanie L. Hutton, Katherine A. Hammer, Daniel R. Knight, Thomas V. Riley, Dena Lyras, Paul A. Keller, Stephen G. Pyne
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Antibiotics
Subjects:
antibacterial
<i>Clostridioides</i> (<i>Clostridium</i>) <i>difficile</i>
peptidomimetic
triazole
Online Access:https://www.mdpi.com/2079-6382/10/8/913

Internet

https://www.mdpi.com/2079-6382/10/8/913

Similar Items