Candida albicans Sap6 Initiates Oral Mucosal Inflammation via the Protease Activated Receptor PAR2

Candida albicans Sap6 Initiates Oral Mucosal Inflammation via the Protease Activated Receptor PAR2

Candida albicans Sap6, a secreted aspartyl protease (Sap), contributes to fungal virulence in oral candidiasis. Beside its protease activity, Sap6 contains RGD (RGDRGD) motif required for its binding to host integrins. Sap6 activates immune cells to induce proinflammatory cytokines, although its abi...

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Bibliographic Details
Main Authors: Rohitashw Kumar, Isolde Gina Rojas, Mira Edgerton
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
oral epithelial cells
Candida albicans
secreted aspartyl protease (Sap6)
protease activated receptor 2
cytokines and chemokines
epithelial barrier break
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.912748/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.912748/full

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