Hydrobromination of alkenes with PBr3/SiO2: a simple and efficient regiospecific preparation of alkyl bromides
The reaction of several alkenes with 0.4 mol equiv. PBr3/SiO2 in dichloromethane at room temperature gave the alkyl bromides with Markovnikov regiospecificity in 50 - 100% yield and short reaction time. Isoprene at - 8 °C in these conditions gave 1-bromo-3-methyl-2-butene only (54%).
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2001-01-01
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| Series: | Journal of the Brazilian Chemical Society |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000500013 |