Hydrobromination of alkenes with PBr3/SiO2: a simple and efficient regiospecific preparation of alkyl bromides
The reaction of several alkenes with 0.4 mol equiv. PBr3/SiO2 in dichloromethane at room temperature gave the alkyl bromides with Markovnikov regiospecificity in 50 - 100% yield and short reaction time. Isoprene at - 8 °C in these conditions gave 1-bromo-3-methyl-2-butene only (54%).
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2001-01-01
|
| Series: | Journal of the Brazilian Chemical Society |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000500013 |
| Summary: | The reaction of several alkenes with 0.4 mol equiv. PBr3/SiO2 in dichloromethane at room temperature gave the alkyl bromides with Markovnikov regiospecificity in 50 - 100% yield and short reaction time. Isoprene at - 8 °C in these conditions gave 1-bromo-3-methyl-2-butene only (54%). |
|---|---|
| ISSN: | 0103-5053 |