Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium tuberculosis

Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium tuberculosis

Numerous studies show efflux as a universal bacterial mechanism contributing to antibiotic resistance and also that the activity of the antibiotics subject to efflux can be enhanced by the combined use of efflux inhibitors. Nevertheless, the contribution of efflux to the overall drug resistance leve...

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Bibliographic Details
Main Authors: Miguel Viveiros, Diana Machado, Tatiane S. Coelho, João Perdigão, Catarina Pereira, Isabel Couto, Isabel Portugal, Raquel De Abreu Maschmann, Daniela F. Ramos, Andrea von Groll, Maria L. R. Rossetti, Pedro A. Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Microbiology
Subjects:
tuberculosis
synergism
efflux inhibitors
TB eXIST
time to detection
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.00711/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.00711/full

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