Parsing the role of NSP1 in SARS-CoV-2 infection

Parsing the role of NSP1 in SARS-CoV-2 infection

Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to shutoff of protein synthesis, and nsp1, a central shutoff factor in coronaviruses, inhibits cellular mRNA translation. However, the diverse molecular mechanisms employed by nsp1 as well as its functional importance are un...

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Bibliographic Details
Main Authors: Tal Fisher, Avi Gluck, Krishna Narayanan, Makoto Kuroda, Aharon Nachshon, Jason C. Hsu, Peter J. Halfmann, Yfat Yahalom-Ronen, Hadas Tamir, Yaara Finkel, Michal Schwartz, Shay Weiss, Chien-Te K. Tseng, Tomer Israely, Nir Paran, Yoshihiro Kawaoka, Shinji Makino, Noam Stern-Ginossar
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Cell Reports
Subjects:
SARS-CoV-2
Nsp1
RNA
Interferon
Host shutoff
Translation regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722007367

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http://www.sciencedirect.com/science/article/pii/S2211124722007367

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