Maternal dendritic cells influence fetal allograft response following murine in-utero hematopoietic stem cell transplantation

Maternal dendritic cells influence fetal allograft response following murine in-utero hematopoietic stem cell transplantation

Abstract Background Intrauterine hematopoietic stem cell transplantation (IUT), potentially curative in congenital haematological disease, is often inhibited by deleterious immune responses to donor cells resulting in subtherapeutic donor cell chimerism (DCC). Microchimerism of maternal immune cells...

Full description

Bibliographic Details
Main Authors: Karthikeyan Kandasamy, Nuryanti Binti Johana, Lay Geok Tan, Yvonne Tan, Julie Su Li Yeo, Nur Nazneen Binte Yusof, Zhihui Li, Jiayu Koh, Florent Ginhoux, Jerry K. Y. Chan, Mahesh Choolani, Citra N. Z. Mattar
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Stem Cell Research & Therapy
Subjects:
Hematopoietic stem cells
In-utero transplantation
Fetal tolerance
Maternal microchimerism
Online Access:https://doi.org/10.1186/s13287-023-03366-9

Internet

https://doi.org/10.1186/s13287-023-03366-9

Similar Items