The impact of serotype-specific vaccination on phylodynamic parameters of Streptococcus pneumoniae and the pneumococcal pan-genome.

The impact of serotype-specific vaccination on phylodynamic parameters of Streptococcus pneumoniae and the pneumococcal pan-genome.

In the United States, the introduction of the heptavalent pneumococcal conjugate vaccine (PCV) largely eliminated vaccine serotypes (VT); non-vaccine serotypes (NVT) subsequently increased in carriage and disease. Vaccination also disrupts the composition of the pneumococcal pangenome, which include...

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Bibliographic Details
Main Authors: Taj Azarian, Lindsay R Grant, Brian J Arnold, Laura L Hammitt, Raymond Reid, Mathuram Santosham, Robert Weatherholtz, Novalene Goklish, Claudette M Thompson, Stephen D Bentley, Katherine L O'Brien, William P Hanage, Marc Lipsitch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5902063?pdf=render

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