Activation of a Silent Polyketide Synthase SlPKS4 Encoding the C<sub>7</sub>-Methylated Isocoumarin in a Marine-Derived Fungus <i>Simplicillium lamellicola</i> HDN13-430

Activation of a Silent Polyketide Synthase SlPKS4 Encoding the C<sub>7</sub>-Methylated Isocoumarin in a Marine-Derived Fungus <i>Simplicillium lamellicola</i> HDN13-430

Coumarins, isocoumarins and their derivatives are polyketides abundant in fungal metabolites. Although they were first discovered over 50 years ago, the biosynthetic process is still not entirely understood. Herein, we report the activation of a silent nonreducing polyketide synthase that encodes a...

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Bibliographic Details
Main Authors: Jing Yu, Xiaolin Liu, Chuanteng Ma, Chen Li, Yuhan Zhang, Qian Che, Guojian Zhang, Tianjiao Zhu, Dehai Li
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Marine Drugs
Subjects:
isocoumarins
nonreducing polyketide synthase (nrPKS)
<i>Simplicillium lamellicola</i>
genome mining
silent gene clusters
Online Access:https://www.mdpi.com/1660-3397/21/9/490

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https://www.mdpi.com/1660-3397/21/9/490

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