Capsaicin as an amphipathic modulator of NaV1.5 mechanosensitivity

SCN5A-encoded NaV1.5 is a voltage-gated Na+ channel that drives the electrical excitability of cardiac myocytes and contributes to slow waves of the human gastrointestinal smooth muscle cells. NaV1.5 is mechanosensitive: mechanical force modulates several facets of NaV1.5’s voltage-gated function, a...

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Bibliographic Details
Main Authors: Luke M. Cowan, Peter R. Strege, Radda Rusinova, Olaf S. Andersen, Gianrico Farrugia, Arthur Beyder
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Channels
Subjects:
Online Access:https://www.tandfonline.com/doi/10.1080/19336950.2022.2026015