Regulatory Effects of <i>GPR158</i> Overexpression in Trabecular Meshwork Cells of the Eye’s Aqueous Outflow Pathways

Regulatory Effects of <i>GPR158</i> Overexpression in Trabecular Meshwork Cells of the Eye’s Aqueous Outflow Pathways

Elevated intraocular pressure (IOP), the major risk factor for glaucoma, is caused by decreased outflow through the trabecular meshwork (TM). The pathophysiology of ocular hypertension has been linked to stress pathways, including fibrosis, calcification and the unfolded protein response (UPR). In a...

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Bibliographic Details
Main Authors: Maria Fernanda Suarez, Tatsuo Itakura, Satyabrata Pany, Shinwu Jeong, Shravan K. Chintala, Michael B. Raizman, Steven Riesinger, Tsvetelina Lazarova, José Echenique, Horacio M. Serra, W. Daniel Stamer, M. Elizabeth Fini
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Stresses
Subjects:
ocular hypertension
glaucoma
G-protein-coupled receptor
GPR158
dexamethasone
TGFB1
Online Access:https://www.mdpi.com/2673-7140/3/3/44

Internet

https://www.mdpi.com/2673-7140/3/3/44

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