Induction of NK cell reactivity against acute myeloid leukemia by Fc-optimized CD276 (B7-H3) antibody

Induction of NK cell reactivity against acute myeloid leukemia by Fc-optimized CD276 (B7-H3) antibody

Abstract Acute myeloid leukemia (AML) remains a therapeutic challenge despite recent therapeutic advances. Although monoclonal antibodies (mAbs) engaging natural killer (NK) cells via antibody-dependent cellular cytotoxicity (ADCC) hold promise in cancer therapy, almost none have received clinical a...

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Bibliographic Details
Main Authors: Sylwia A. Stefańczyk, Ilona Hagelstein, Martina S. Lutz, Stefanie Müller, Samuel J. Holzmayer, Grace Jarjour, Latifa Zekri, Jonas S. Heitmann, Helmut R. Salih, Melanie Märklin
Format: Article
Language:English
Published: Nature Publishing Group 2024-04-01
Series:Blood Cancer Journal
Online Access:https://doi.org/10.1038/s41408-024-01050-6

Internet

https://doi.org/10.1038/s41408-024-01050-6

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